As mandated by the States Parties,
- the ISU liaises and collaborates regularly with the International Campaign to Ban Landmines,
- the International Committee of the Red Cross,
- United Nations departments and agencies and,
- the Geneva International Centre for Humanitarian Demining.
In addition, the ISU has deepened relations with other organisations, including
- UN agencies and non-governmental organisations that focus on disability issues and international organisations that support the implementation of the Convention on the Rights of Persons with Disabilities.